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Adrenergic Transmission



Adrenergic Transmission

  • Neurotransmitter: Noradrenaline (Norepinephrine)

  • Sites

    • Sympathetic postganglionic neuron.

      • Except: Sweat glands, some vasodilator fibers

    • Brain


Steps

Tyrosine

Tyrosine hydroxylase

DOPA

DOPA decarboxylase

Dopamine

Transported into the vesicle by Vesicular Monoamine Transporter (VMAT)

Dopamine

β hydroxylase

Noradrenaline

Complexed with ATP ⟶ adsorbed on chromogranin

Nerve impulse coupled release

Acts on adrenergic receptors on postsynaptic membrane

1. 75-90% is taken back in nerve terminal by Norepinephrine transporter(NET) ⟶ most of it is transported into the vesicle by VMAT; some is degraded by Monoamine Oxidase (MAO).

2. Some noradrenaline diffuses away ⟶ Degraded by Catechol O Methytransfarase (COMT).

 

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