Redistribution of Drugs
In simple words, redistribution means the drug initially goes to certain organs and then from there, it goes to some other organs.
This is seen with highly lipid-soluble drugs because lipid-soluble drugs cross the biological membranes easily.
We administer a drug
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it first gets distributed to organs with high blood supply. e.g. brain, kidney, heart
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being lipid soluble, it diffuses back rapidly
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gets redistributed to less vascular but more bulky organs e.g. adipose tissue, muscles
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If the site of action of the drug is an organ with a high blood supply e.g. thiopentone used for general anesthesia.
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first distribution produces rapid action
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But soon the redistribution leads to the termination of the action.