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Terminal Half-Life



When multiple doses of the drug are given

the drug accumulates in various body tissues apart from blood

when we stop giving the drug

plasma concentration of the drug falls due to elimination

drug starts diffusing back from its storage sites into the plasma

plasma half-life of the drug gets prolonged as compared to that during steady state.

half-life during the terminal stage of elimination is called terminal half-life.


  • E.g. for gentamicin, half-life during steady state is about 3 hours but the terminal half-life is about 50 hours

 

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