- Vipul Navadiya
- Jun 16, 2022
- 1 min read
Updated: Feb 7, 2023
Terminal Half-Life
When multiple doses of the drug are given
↓
the drug accumulates in various body tissues apart from blood
↓
when we stop giving the drug
↓
plasma concentration of the drug falls due to elimination
↓
drug starts diffusing back from its storage sites into the plasma
↓
plasma half-life of the drug gets prolonged as compared to that during steady state.
↓
half-life during the terminal stage of elimination is called terminal half-life.
E.g. for gentamicin, half-life during steady state is about 3 hours but the terminal half-life is about 50 hours
Comments