- Jun 16, 2022
- 1 min read
Updated: Feb 7, 2023
Clearance in First Order and Zero Order Elimination Kinetic
Clearance is an imaginary volume of plasma from which a drug is completely removed in unit time.
↓
elimination process is not saturated
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at higher concentrations of drug → more drug molecules are eliminated &
at lower concentrations of drug → less drug molecules are eliminated
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the volume of plasma from which drug is completely removed remains constant
↓ i.e. clearance remains constant.
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elimination process is saturated
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fixed number of drug molecules are eliminated irrespective of plasma concentration of drug
↓ at higher concentrations → less plasma is cleared &
at lower concentrations → more plasma is cleared
↓
i.e. clearance is not constant.
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