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Clearance in First Order and Zero Order Elimination Kinetic

  • Clearance is an imaginary volume of plasma from which a drug is completely removed in unit time.

elimination process is not saturated

at higher concentrations of drug more drug molecules are eliminated &

at lower concentrations of drug less drug molecules are eliminated

the volume of plasma from which drug is completely removed remains constant

i.e. clearance remains constant.

elimination process is saturated

fixed number of drug molecules are eliminated irrespective of plasma concentration of drug

at higher concentrations less plasma is cleared &

at lower concentrations more plasma is cleared

i.e. clearance is not constant.


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